26 March 2022

American black population more vulnerable to the Omicron variant of SARS-CoV-2

The spread of the Omicron variant of the SARS-CoV-2 virus has turned the number of COVID-19 cases up again. In Finland, the number of daily deaths have during the last weeks been the highest during the epidemic that started more than two years ago. Globally, however, the number of deaths were higher in January and May 2021. 

Omicron variant is known to cause less serious symptoms compared to previous variants of concern, and thus the death rate per the number of infections is lower. Therefore it was highly interesting to read from the Science magazine about research conducted in the USA on COVID-19 related differences between ethnic groups. 

The leading American science-journal reported that black adults were hospitalized for this disease at four times higher rate compared to white adults. The difference between the two groups was 40% versus 47% after two vaccinations and 44% versus 55% if they were given a booster. However, in both groups the hospital stays for Omicron were shorter compared to those caused by the previously common Delta variant, namely 5 days versus 4 days, and intensive care was not needed that often. 

The question that came to my mind was, whether this racial difference has something to do with the genes from archaic humans, Neanderthals, which do not occur in African groups of people. That was because it was previously noted that in the UK people with South Asian roots died for corona considerably more often that those associated with other ethnic groups - and the explanation was the genetic inheritance from the Neanderthals, which made them more susceptible for the virus. 

It was, however, also noticed that the same genes were rare among people of the easternmost Asia, possibly due to prehistoric selection caused by ancient viruses related to SARS-CoV-2. So, could it be possible, that most people with roots outside Africa, have some - yet unknown - genes associated with a higher tolerance to the Omicron virus? 

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