The Dire Wolf and the Rights of Extinct Human Species

The Americans have announced that they have brought back to life a dire wolf that lived during the Ice Age. Or, more precisely, they have created a hybrid — a cross between a gray wolf and an ancient dire wolf.

This was made possible by two things. First, the genome of the dire wolf has been successfully determined from fossil material. And second, the general advancement of methods for modifying the DNA of living organisms.

The case is the first of its kind and particularly interesting because the animal species in question is not actually very closely related to the wolf. Instead, it belongs to an entirely different genus within the canine family. Thus, quite a lot of genetic modifications had to be made, and the resulting animals may not — or even likely will not — behave like the original dire wolves.

It remains to be seen what will happen to these hybrid animals in the future. Will they become free predators roaming the North American wilderness, or — as I rather suspect — exhibition pieces harnessed for profit in zoos or even in some kind of traveling shows? It will also be interesting to see whether this revival of the dire wolf will be followed by attempts to bring back other extinct creatures, like mammoths or thylacines.

One thing is certain, however: the creation of these animals will spark lively debate about the ethics of science. And there is little doubt that the most heated discussions will center around humanity’s own relatives.

After all, with the methods that have now been successfully used, it is possible — at least in theory — to also bring back extinct human species. Such as Neanderthals, Denisovans, or even Homo erectus.

If that were to happen, difficult questions would arise. For example, regarding whether they should be granted the same human and civil rights as everyone else.

Previous thoughts on the same topic:
The Historical Merging of Human Groups
Number of Predators is Increasing in Russia
African female and Persian male ancestors

The Historical Merging of Human Groups

Understanding human evolution has progressed step by step during my lifetime. One of the most sensational discoveries was the evidence of interbreeding between Neanderthals, who lived in Europe before modern humans, and our ancestors.

Significant new information has once again been obtained on this matter. It was based on an excellent idea: previously, the focus had been on determining how much Neanderthal DNA is present in our genes, but now researchers decided to investigate how much so-called modern human DNA is present in Neanderthal genes.

This was possible using two criteria. The first was based on the fact that Neanderthals were already known to be much fewer in number than modern humans, so their genomes likely contained less variation. Thus, the more variable regions of the Neanderthal genome would be possible gene regions originating from modern humans.

When such gene regions were then found, the corresponding segments of heritage could be searched for in modern Africans, who have never interbred with Neanderthals. If they had similar genome segments to the now-found more variable regions, they must have developed in modern humans and not in Neanderthals. And indeed, this confirmed that as much as about ten percent of Neanderthal genes ultimately came from modern humans.

Based on this new information, it can also be concluded that Neanderthals may not have disappeared from the world after all but simply merged into the much more numerous populations of modern humans. And they left their genetic mark on them— a set of genes that developed in Neanderthals and have since been passed down to me and to all of you, dear readers, unless you are entirely of African descent.

Previous thoughts on the same topic:
The amazing adventures of the German cockroach
Violent demographic changes in Denmark
American black population more vulnerable to the Omicron variant of SARS-CoV-2

American black population more vulnerable to the Omicron variant of SARS-CoV-2

The spread of the Omicron variant of the SARS-CoV-2 virus has turned the number of COVID-19 cases up again. In Finland, the number of daily deaths have during the last weeks been the highest during the epidemic that started more than two years ago. Globally, however, the number of deaths were higher in January and May 2021. 

Omicron variant is known to cause less serious symptoms compared to previous variants of concern, and thus the death rate per the number of infections is lower. Therefore it was highly interesting to read from the Science magazine about research conducted in the USA on COVID-19 related differences between ethnic groups. 

The leading American science-journal reported that black adults were hospitalized for this disease at four times higher rate compared to white adults. The difference between the two groups was 40% versus 47% after two vaccinations and 44% versus 55% if they were given a booster. However, in both groups the hospital stays for Omicron were shorter compared to those caused by the previously common Delta variant, namely 5 days versus 4 days, and intensive care was not needed that often. 

The question that came to my mind was, whether this racial difference has something to do with the genes from archaic humans, Neanderthals, which do not occur in African groups of people. That was because it was previously noted that in the UK people with South Asian roots died for corona considerably more often that those associated with other ethnic groups - and the explanation was the genetic inheritance from the Neanderthals, which made them more susceptible for the virus. 

It was, however, also noticed that the same genes were rare among people of the easternmost Asia, possibly due to prehistoric selection caused by ancient viruses related to SARS-CoV-2. So, could it be possible, that most people with roots outside Africa, have some - yet unknown - genes associated with a higher tolerance to the Omicron virus? 

Previous thoughts on the same topic:
An ignorant mediahouse failed again in historical facts
Vikings and the technological cutting edge